🔹 What are Substance P Antibodies?

Substance P antibodies are immunoglobulins that specifically recognize Substance P, a neuropeptide involved in pain perception, inflammation, and neuroimmune signaling. These antibodies are widely used in research, diagnostic assays, and therapeutic development to study Substance P–mediated pathways.

🔹 Key Features

• Specificity:

  • High affinity for Substance P, enabling selective detection and neutralization.

• Types of Antibodies:

  • Monoclonal antibodies (mAbs): Target specific epitopes on Substance P.

  • Polyclonal antibodies (pAbs): Broader recognition for detection in multiple assays.

  • Conjugated antibodies: Labeled with enzymes, fluorophores, or other reporters for ELISA, immunofluorescence, or Western blot.

• Formats and Modifications:

  • Full-length IgG, Fab fragments, humanized or chimeric variants.

  • Functional for neutralization, immunodetection, and mechanistic studies.

🔹 Applications

• Mechanistic Studies:

  • Investigate pain pathways, neuroinflammation, and neuropeptide signaling.

• Diagnostics:

  • Detection of Substance P in tissue, serum, or cerebrospinal fluid.

• Therapeutic Research:

  • Evaluate Substance P–targeting strategies for pain management, inflammatory diseases, or neurological disorders.

• Functional Assays:

  • Receptor binding, signaling pathway modulation, and interaction with other neuropeptides.

✅ In summary:
Substance P antibodies are highly specific tools for research, diagnostics, and therapeutic studies, enabling detection, neutralization, and mechanistic analysis of Substance P and its biological functions.