How does Klonopin work?, Dosages ,Side Effects & Uses. Klonopin is a benzodiazepine drug that’s mainly used for treating anxiety disorders and seizures. The drug works on the nervous system by targeting the neurotransmitter GABA. GABA, which is naturally present in the brain, helps to regulate nerve activity. It promotes relaxation and reduces overactivity. Klonopin increases the...