🔹 What is the EXLow™ Non-Detergent Assay?

The EXLow™ Non-Detergent Assay is a specialized platform for extracellular vesicle (EV) analysis and quantification that operates without the use of detergents. By avoiding detergents, the assay preserves vesicle integrity, native protein conformations, and biological activity, providing more accurate measurements and functional assessments.

This approach is particularly useful for exosome research, biomarker discovery, and therapeutic development.

🔹 Key Features

  • Detergent-Free:

    • Maintains intact vesicle membranes and native protein structures.

  • High Sensitivity & Specificity:

    • Detects EVs across a broad size range (exosomes, microvesicles).

    • Minimizes background interference from free proteins or debris.

  • Quantitative and Functional:

    • Enables EV counting, protein quantification, and functional assays without compromising vesicle activity.

  • Compatible with Downstream Analysis:

    • Supports proteomics, nucleic acid profiling, and EV-based functional studies.

🔹 Applications

  • EV Characterization:

    • Size distribution, concentration, and surface protein profiling.

  • Biomarker Discovery:

    • Identification of disease- or condition-specific EV signatures.

  • Therapeutic Development:

    • Functional assessment of EVs for drug delivery or regenerative medicine.

  • Comparative Studies:

    • Evaluating EV integrity and activity under different treatments or isolation methods.

âś… In summary:
The EXLow™ Non-Detergent Assay provides a sensitive, detergent-free platform for accurate extracellular vesicle quantification and functional analysis, supporting biomarker discovery, therapeutic evaluation, and fundamental EV research.