🔹 What is Calicheamicin Synthesis? Calicheamicin synthesis refers to the chemical preparation of calicheamicins, a family of ultra-potent enediyne antitumor antibiotics originally derived from Micromonospora echinospora. Calicheamicins bind to the minor groove of DNA and induce site-specific double-strand breaks, leading to apoptosis in target cells. Due to their extreme cytotoxicity,...